1,2-Dichloroethane → HCID 67507904, compound

Participants

Reaction Steps

Prepared according to Procedure U by stirring 3-(7-fluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-ylamino)-5-morpholinobenzoic acid (0.030 g, 0.065 mmol), DMAP (0.016 g, 0.131 mmol), EDC (0.025 g, 0.131 mmol), cyclopropylamine (6.46 μL, 0.092 mmol), and DCM (0.6 mL) at 23° C. for 1 hour. Purification by reverse-phase HPLC afforded N-cyclopropyl-3-((7-fluoro-3-methyl-2-(2-pyridinyl)-4-quinolinyl)amino)-5-(4-morpholinyl)benzamide as a yellow amorphous solid. 1H NMR (400 MHz, DMSO-d6) δ ppm 8.68-8.71 (1H, m), 8.61 (1H, s), 8.24 (1H, d, J=4.3 Hz), 8.08 (1H, dd, J=9.3, 6.2 Hz), 7.99 (1H, dd, J=7.6, 1.8 Hz), 7.85-7.89 (1H, m), 7.74 (1H, dd, J=10.4, 2.7 Hz), 7.45-7.51 (2H, m), 6.82-6.84 (1H, m), 6.59-6.61 (1H, m), 6.44 (1H, t, J=2.2 Hz), 3.68-3.74 (4H, m), 3.04-3.09 (4H, m), 2.76 (1H, m), 2.18 (3H, s), 0.60-0.69 (2H, m), 0.51 (2H, dd, J=4.2, 2.2 Hz). Mass Spectrum (ESI) m/e=498.0 (M+1).

Provenance & Evidence