1,2-Dichloroethane → HCID 67508605, compound

Participants

Reaction Steps

Prepared according to Procedure U by stirring 3-(7-fluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-ylamino)-5-morpholinobenzoic acid (0.025 g, 0.055 mmol), DMAP (0.013 g, 0.109 mmol), EDC (0.021 g, 0.109 mmol), 2M ethanamine THF (0.035 mL, 0.071 mmol), and DCM (0.6 mL) at 23° C. for 1 hour. Purification by reverse-phase HPLC afforded N-ethyl-3-((7-fluoro-3-methyl-2-(2-pyridinyl)-4-quinolinyl)amino)-5-(4-morpholinyl)benzamide as a yellow amorphous solid. 1H NMR (400 MHz, DMSO-d6) δ ppm 8.67-8.71 (1H, m), 8.61 (1H, s), 8.27 (1H, m), 8.09 (1H, dd, J=9.3, 6.2 Hz), 7.97-8.02 (1H, m), 7.84-7.91 (1H, m), 7.71-7.77 (1H, m), 7.45-7.52 (2H, m), 6.86-6.89 (1H, m), 6.59-6.62 (1H, m), 6.44-6.48 (1H, m), 3.69-3.75 (4H, m), 3.17-3.25 (2H, m), 3.05-3.11 (4H, m), 2.16-2.20 (3H, m), 1.04-1.10 (3H, m). Mass Spectrum (ESI) m/e=486.2 (M+1).

Provenance & Evidence