1,2-Dichloroethane → HCID 59631415, compound

Participants

Reaction Steps

Prepared according to Procedure U by stirring 3-(7-fluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-ylamino)-5-morpholinobenzoic acid (0.014 g, 0.031 mmol), DMAP (7.46 mg, 0.061 mmol), EDC (0.023 g, 0.122 mmol), 0.5M ammonia in dioxane (0.092 mL, 0.046 mmol), and DCM (0.3 mL) at 23° C. for 48 h. Reverse-phase HPLC afforded 3-((7-fluoro-3-methyl-2-(2-pyridinyl)-4-quinolinyl)amino)-5-(4-morpholinyl)benzamide as a yellow amorphous solid. 1H NMR (400 MHz, Methanol) δ ppm 8.72 (1H, br. s.), 7.98-8.27 (2H, m), 7.82 (1H, d, J=7.2 Hz), 7.67 (1H, d, J=9.6 Hz), 7.59 (1H, d, J=3.9 Hz), 7.39 (1H, m), 7.08 (1H, br. s.), 6.77 (1H, br. s.), 6.66 (1H, br. s.), 3.70-3.94 (4H, m), 3.03-3.25 (5H, m), 2.01-2.24 (3H, m). Mass Spectrum (ESI) m/e=457.2 (M+1).

Provenance & Evidence