Potassium Phosphate, Tribasic → N-(3-morpholino-5-nitrophenyl)isobutyramide

Participants

Reaction Steps

Prepared according to Procedure W by stirring palladium (II) acetate (0.028 g, 0.124 mmol), tetramethyl tert-butyl XPhos (0.178 g, 0.371 mmol), 4-(3-chloro-5-nitrophenyl)morpholine (0.300 g, 1.236 mmol), isobutyramide (0.129 g, 1.484 mmol), potassium phosphate (0.367 g, 1.731 mmol), and tert-butanol (3 mL) at 110° C. for 4 h. Purification by column chromatography (silica; 0-30% EtOAc in hexanes) afforded N-(3-morpholino-5-nitrophenyl)isobutyramide as an orange amorphous solid. Mass Spectrum (ESI) m/e=293.9 (M+1).

Provenance & Evidence