HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (2S,3R)-3-(n-butyl)-2-hydroxysuccinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | (2S,3R)-3-(n-butyl)-2-hydroxysuccinic dimethyl ester | HCID 23520166 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | (2S,3R)-3-(n-butyl)-2-hydroxysuccinic acid | HCID 60111363 | — |
Reaction Steps
To (2S,3R)-3-(n-butyl)-2-hydroxysuccinic dimethyl ester B-3 in MeOH (28 mL) is added a solution of NaOH (2.2 g, 55 mmol) in water (28 mL). After 24 hours, the MeOH is removed, the crude reaction is acidified with HCl (6 N, 12 mL) to pH=1, and then extracted with EtOAc (3×50 mL). The combined organic layers are dried (Na2SO4) and concentrated to give (2S,3R)-3-(n-butyl)-2-hydroxysuccinic acid B-4.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07612059B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-57aaeaff567b4e57b47ce42fb96bba57 |
| Source note | uspto-grants-2009_11 |