4-(Pyrrolidin-3-yl)pyridine → 2(S)-hydroxy-3(R)-[3(R/S)-pyridin-4-yl-pyrrolidine-1-carbonyl)-heptanoic acid

HRID 1431946Notes

Reaction equation

HRID 1431946 reaction equation
CC1(C)[O:6][C:5](=[O:7])[CH:4]([CH:8]([CH2:12][CH2:13][CH2:14][CH3:15])[C:9]([OH:11])=O)[O:3]1.[NH:17]1[CH2:21][CH2:20][CH:19]([C:22]2[CH:27]=[CH:26][N:25]=[CH:24][CH:23]=2)[CH2:18]1>>[OH:3][C@@H:4]([C@H:8]([C:9]([N:17]1[CH2:21][CH2:20][CH:19]([C:22]2[CH:23]=[CH:24][N:25]=[CH:26][CH:27]=2)[CH2:18]1)=[O:11])[CH2:12][CH2:13][CH2:14][CH3:15])[C:5]([OH:6])=[O:7]

Participants

3

Reactant 2

HCID 49931054-(Pyrrolidin-3-yl)pyridineHCID 22256526HCID 22256526, compound

Product 1

HCID 1317277062(S)-hydroxy-3(R)-[3(R/S)-pyridin-4-yl-pyrrolidine-1-carbonyl)-heptanoic acid

Procedure

The title compound is prepared from 2-(2,2-dimethyl-4-oxo-1,3-dioxolan-5-yl)hexanoic acid B-5 and commercially available 4-pyrrolidin-3-yl-pyridine A-5 according to General Procedure B.

Sources & evidence

ORD record
ord-24ba5225d00742d5ad6fed9d1a8c1c78
Source dataset
uspto-grants-2009_11
Patent number
US07612059B2

Reaction notes

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