4-(N-Boc-amino)piperidine → HCID 86608431, compound

HRID 1431959Notes

Reaction equation

HRID 1431959 reaction equation
[O:1]1[CH:11]2[CH:2]1[CH2:3][O:4][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][C:10]=12.[NH:12]1[CH2:17][CH2:16][CH:15]([NH:18][C:19](=[O:25])[O:20][C:21]([CH3:24])([CH3:23])[CH3:22])[CH2:14][CH2:13]1>C(#N)C>[OH:1][C@H:2]1[C@H:11]([N:12]2[CH2:13][CH2:14][CH:15]([NH:18][C:19](=[O:25])[O:20][C:21]([CH3:23])([CH3:22])[CH3:24])[CH2:16][CH2:17]2)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[O:4][CH2:3]1

Participants

4

Reactant 2

HCID 7238334-(N-Boc-amino)piperidineHCID 131490333,6-Dioxatricyclo[5.4.0.0,2,4]undeca-1(11),7,9-triene

Product 1

HCID 86608431HCID 86608431, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To 3 g of the compound obtained in Step B of Example 4, dissolved in 45 ml of acetonitrile, there are added 4 g of tert-butyl piperidin-4-ylcarbamate (20.2 mmol). The mixture is then heated at reflux for 12 hours and subsequently evaporated to dryness. A yellow oil is obtained which is purified by flash chromatography on silica (eluant: dichloromethane/ethanol 95/5) to yield the expected product in the form of a pale-yellow meringue.

Workup

  1. temperatureThe mixture is then heated
  2. temperatureat reflux for 12 hours
  3. customsubsequently evaporated to dryness
  4. customA yellow oil is obtained which
  5. customis purified by flash chromatography on silica (eluant: dichloromethane/ethanol 95/5)

Sources & evidence

ORD record
ord-9e07addf73204b6bbe190e091b2f3e51
Source dataset
uspto-grants-2009_11
Patent number
US07612061B2

Reaction notes

Loading…