Benzenesulfonyl chloride → HCID 86604862, compound

Participants

Reaction Steps

A mixture of d-propargylglycine (32.10 g, 88.46 mmol), Na2CO3 (20.62 g, 194.6 mmol), and benzenesulfonyl chloride (18.74 g, 106.2 mmol) in p-dioxane/H2O (1:1, 200 ml) was stirred overnight at rt. The reaction mixture was concentrated and the ph adjusted to 4.0 with 10% hcl. The aqueous layer was extracted with CHCl3 (3×), dried over mgso4, and concentrated to give the title compound. 1H NMR (400 mhz, CDCl3): δ 2.04 (s, 1h), 2.65 (s, 3h), 2.71 (m, 2h), 4.11 (m, 1h), 5.61 (d, 8.4 hz, 1h), 7.61 (m, 3h), 7.88 (m, 2h).

Provenance & Evidence