HCID 86604861, compound → HCID 87653127, compound

HRID 1432001Notes

Reaction equation

HRID 1432001 reaction equation
[CH3:1][O:2][CH:3]([O:22][CH3:23])[CH2:4][NH:5][C:6](=[O:21])[C@H:7]([NH:11][S:12]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)(=[O:14])=[O:13])[CH2:8][C:9]#[CH:10].[Cl:24]C1C=CC(S(N[C@H](CC#C)C(O)=O)(=O)=O)=CC=1>>[CH3:23][O:22][CH:3]([O:2][CH3:1])[CH2:4][NH:5][C:6](=[O:21])[C@H:7]([NH:11][S:12]([C:15]1[CH:16]=[CH:17][C:18]([Cl:24])=[CH:19][CH:20]=1)(=[O:14])=[O:13])[CH2:8][C:9]#[CH:10]

Participants

3

Reactant 2

HCID 86604861HCID 86604861, compoundHCID 87653945HCID 87653945, compound

Product 1

HCID 87653127HCID 87653127, compound

Procedure

Using the same procedure describe for the synthesis of 39, (R)-2-(4-chlorobenzenesulfonamido)pent-4-ynoic acid afforded the title compound. 1H NMR (400 MHz, CDCl3): δ 2.43 (m, 2H), 2.71 (s, 3H), 2.85 (s, 1H), 2.89 (s, 3H), 2.96 (m, 2H), 3.98 (t, 7.1 Hz, 3H), 4.15 (t, 5.5 Hz, 1H), 7.65(d, 8.0 Hz, 2H), 7.80 (d, 8.0 Hz, 2H), 7.97 (s, 1H), 8.11 (t, 5.5 Hz, 1H).

Sources & evidence

ORD record
ord-52a0a5cff33246c88aa528348eab016a
Source dataset
uspto-grants-2009_11
Patent number
US07612060B2

Reaction notes

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