HCID 86604861, compound → HCID 87653836, compound

HRID 1432002Notes

Reaction equation

HRID 1432002 reaction equation
[CH3:1][O:2][CH:3]([O:22][CH3:23])[CH2:4][NH:5][C:6](=[O:21])[C@H:7]([NH:11][S:12]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)(=[O:14])=[O:13])[CH2:8][C:9]#[CH:10].[F:24][C:25]([F:44])([F:43])C1C=C(S(N[C@H](CC#C)C(O)=O)(=O)=O)C=CC=1>>[CH3:23][O:22][CH:3]([O:2][CH3:1])[CH2:4][NH:5][C:6](=[O:21])[C@H:7]([NH:11][S:12]([C:15]1[CH:16]=[CH:17][CH:18]=[C:19]([C:25]([F:44])([F:43])[F:24])[CH:20]=1)(=[O:14])=[O:13])[CH2:8][C:9]#[CH:10]

Participants

3

Reactant 2

HCID 86604861HCID 86604861, compoundHCID 87653933HCID 87653933, compound

Product 1

HCID 87653836HCID 87653836, compound

Procedure

Using the same procedure describe for the synthesis of 39, (R)-2-(3-trifluoromethylbenzenesulfonamido)pent-4-ynoic acid afforded the title compound. 1H NMR (300 MHz, CDCl3): δ 2.05 (s, 1H), 2.65 (m, 2H), 2.85 (s, 3H), 2.96 (s, 3H), 3.35 (m, 2H), 3.96 (t, 6.3 Hz, 1H), 4.32 (t, 5.4 Hz, 1H), 6.86 (t, 5.4 Hz, 1H), 7.68 (t, 7.8 Hz, 1H), 7.82 (d, 7.8 Hz, 1H), 7.97 (s5; 1H), 8.03 (d, 7.8 Hz, 1H), 8.11 (s, 1H).

Sources & evidence

ORD record
ord-42599114354d4e9d8779010d9381d014
Source dataset
uspto-grants-2009_11
Patent number
US07612060B2

Reaction notes

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