HCID 86604865, compound → HCID 86604864, compound

HRID 1432004Notes

Reaction equation

HRID 1432004 reaction equation
C1(S(N2C=CNC(=O)[C@H]2CC#C)(=O)=O)C=CC=CC=1.CO[CH:22](OC)[CH2:23][NH:24][C:25](=[O:42])[C@H:26]([NH:30][S:31]([C:34]1[CH:39]=[CH:38][C:37]([O:40][CH3:41])=[CH:36][CH:35]=1)(=[O:33])=[O:32])[CH2:27][C:28]#[CH:29]>>[O:40]([C:37]1[CH:38]=[CH:39][C:34]([S:31]([N:30]2[CH:22]=[CH:23][NH:24][C:25](=[O:42])[C@H:26]2[CH2:27][C:28]#[CH:29])(=[O:33])=[O:32])=[CH:35][CH:36]=1)[CH3:41]

Participants

3

Reactant 2

HCID 86604865HCID 86604865, compoundHCID 86604866HCID 86604866, compound

Product 1

HCID 86604864HCID 86604864, compound

Procedure

Using the procedure described for compound 45, (R)-N-(2,2-dimethoxyethyl)-2-(4-methoxybenzenesulfonamido)pent-4-ynamide afforded the title compound as a tan solid. 1H NMR (300 MHz, DMSO-d6): δ 2.45 (m, 2H), 2.96 (s, 1H), 3.89 (s, 3H), 4.38 (t, 7.0 Hz, 1H), 5.98 (m, 2H), 7.09 (d, 8.3 Hz, 2H), 7.76 (d, 8.3 Hz, 2H), 9.65 (d, 5.4 Hz, 1H).

Sources & evidence

ORD record
ord-74198520e9b54eae8ebedaa7736aef79
Source dataset
uspto-grants-2009_11
Patent number
US07612060B2

Reaction notes

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