HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium borohydride → 2-(2-(Tert-butyldiphenylsilyloxy)ethyl)-5,6,7,8-tetrahydro-quinazolin-5-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 2-(2-(tert-butyldiphenylsilyloxy)ethyl)-7,8-dihydroquinazolin-5(6H)-one | HCID 58841347 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-(2-(Tert-butyldiphenylsilyloxy)ethyl)-5,6,7,8-tetrahydro-quinazolin-5-ol | HCID 58841337 | — |
Reaction Steps
A solution of 2-(2-(tert-butyldiphenylsilyloxy)ethyl)-7,8-dihydroquinazolin-5(6H)-one (2.16 g, 5 mmol) in 30 mL of dry MeOH was treated with NaBH4 (189 mg, 5 mmol). After 5 min, the reaction was quenched with 5 mL of sat. NH4Cl solution. The MeOH was evaporated and the residue was extracted with DCM, dried over Na2SO4 and evaporated. Flash chomatography (SiO2, DCM to EtOAc) gave the desired product as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07612060B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-72733672018a48d4b43f12e4b90e340b |
| Source note | uspto-grants-2009_11 |