Isobutyraldehyde → HCID 11541876, compound

Participants

Reaction Steps

To a solution of ((R)-4-(3,4-dichlorophenylsulfonyl)-3-((1-((R)-1,2,3,4,7,8,9,10-octahydrobenzo[f]isoquinolin-7-yl)-1H-1,2,3-triazol-4-yl)methyl)-3,4-dihydropyrazin-2(1H)-one (220 mg, 0.384 mmol) and isobutyraldehyde (83 mg, 1.15 mmol) in 3 mL of 1,2-dichloroethane was added sodium triacetoxyborohydride (163 mg, 0.768 mmol) and the resulting solution was stirred at RT overnight. The reaction mixture was quenched with sat. NaHCO3, extracted with EtOAc, dried over Na2SO4, filtered and evaporated to dryness. Flash chromatography (SiO2, EtOAc to EtOAc/MeOH=100:7 to 100:12 to 100:14) afforded the title compound as a white solid.

Provenance & Evidence