反应详情

温度

95 °C

A dry round bottomed flask was charged with KOtBu (1.903 g, 17.0 mmol), 5-chloro-2-iodoanisole (4.054 g, 15.1 mmol), Pd2dba3 (144 mg, 0.16 mmol), DPEPhos (176 mg, 0.33 mmol) and 3-fluoro-thiophenol (1.903 g, 17.0 mmol). The flask was evacuated and backfilled with Ar three times. Dry toluene (80 mL) was added and the mixture stirred at 95° C. for 2 h. The mixture was filtered through a pad of silica gel followed by adsorption onto silica gel. After purification by flash chromatography using silica gel, eluting with heptanes/EtOAc, 97:3, the title compound was obtained as a yellow oil (3.41 g, 85%).

1. customThe flask was evacuated
2. additionDry toluene (80 mL) was added
3. filtrationThe mixture was filtered through a pad of silica gel
4. customAfter purification by flash chromatography
5. washeluting with heptanes/EtOAc, 97:3