Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Propylamine | HCID 7852 | — |
| Reactant | 3-Chloro-4-fluorobenzonitrile | HCID 145525 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 58962941 | HCID 58962941 | 94% |
Reaction Steps
Step AR1. A mixture of 3-chloro-4-florobenzonitrile (312 mg, 2 mmol) and propylamine (236 mg, 4 mmol) in THF (4 mL) was heated at 50° C. overnight. After the solvent was removed, the residue was purified by flash chromatography with DCM to give 3-chloro-4-(propylamino)benzonitrile (365 mg, 94%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07612069B2 |
|---|
| Source dataset | uspto-grants-2009_11 |
|---|
| ORD ID | ord-72e3d3eaaa474ae78b043904eceae988 |
|---|
| Source note | uspto-grants-2009_11 |
|---|
