HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → HCID 178496038, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | 2-Methoxyethylamine | HCID 8018 | — |
| Reactant | 4-Nitrophenyl chloroformate | HCID 82129 | — |
| Reactant | HCID 178489178 | HCID 178489178 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 178496038 | HCID 178496038 | — |
Reaction Steps
N-((3-chloro-5-(hydroxymethyl)benzylamino)(amino)methylene)-3-(4-methoxyphenyl)-5-methylisothiazole-4carboxamide (Example 251) (20 mg) was treated with 4-nitrophenyl chloroformate (45 mg) and N-methyl morpholine (100 mg) in CH2Cl2 overnight, then 2-methoxyethanamine (30 mg) was added and stirring continued for 1.5 hours. The title compound was obtained as a white solid after HPLC purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07612069B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-3f4d893075d94721a5101d7ac329460d |
| Source note | uspto-grants-2009_11 |