HCID 68542589, compound → HCID 68542695, compound

Participants

Reaction Steps

A solution of 1.24 g (3.32 mmol) of (E)-(3S,14R)-16-(2-chloro-1-hydroxy-ethyl)-3,4,14-trimethyl-1,4diaza-cyclohexadec-10-ene-2,5-dione in 33 ml EtOH is stirred at rt in the presence of 332 mg 10% Pd/C under a hydrogen atmosphere for 1 h. More catalyst is added (332 mg) and the hydrogenation is continued for 4 h. The catalyst is filtered off and the filtrate evaporated. The residue is purified by chromatography on silica gel (DCM/methanol 95/5) and gives the title compound as a brownish foam (mixture of diastereomers).

Provenance & Evidence