HCID 86611579, compound → HCID 68542589, compound

Participants

Reaction Steps

A solution of 1.38 g (3.44 mmol) hept-6-enoic acid {(S)-1-[(R)-1-(2-chloro-1-hydroxy-ethyl)-3-methyl-hept-6-enylcarbamoyl]-ethyl}-methyl-amide in 17 ml DCM is added dropwise within an hour to a refluxing solution of 146 mg [1,3-bis-(2,4,6-trimethylphenyl)-2-imidazolidinylidene)-dichloro(phenylmethylene)-(tricyclohexylphosphine)ruthenium](Grubbs II catalyst) in 340 ml DCM. The mixture is refluxed for an additional hour and the solvent evaporated. The residue is purified by chromatography on silica gel (DCM/methanol 95/5), giving the desired product as a brownish foam (mixture of diastereomers).

Provenance & Evidence