HCID 91026975, compound → HCID 69065520, compound

HRID 1432091Notes

Reaction equation

HRID 1432091 reaction equation
[CH3:1][C@H:2]1[C:17](=[O:18])[NH:16][C@H:15]([C@@H:19]2[CH2:23][C@@H:22]([CH3:24])[C:21](=[O:25])[O:20]2)[CH2:14][C@H:13]([CH3:26])[CH2:12][CH2:11][CH:10]=[CH:9][CH2:8][CH2:7][CH2:6][CH2:5][S:4](=[O:28])(=[O:27])[CH2:3]1>C(N)CCC>[CH2:15]([NH:16][C:21](=[O:25])[C@H:22]([CH3:24])[CH2:23][C@@H:19]([C@@H:15]1[CH2:14][C@H:13]([CH3:26])[CH2:12][CH2:11][CH:10]=[CH:9][CH2:8][CH2:7][CH2:6][CH2:5][S:4](=[O:28])(=[O:27])[CH2:3][C@@H:2]([CH3:1])[C:17](=[O:18])[NH:16]1)[OH:20])[CH2:14][CH2:13][CH3:12]

Participants

3

Reactant 1

HCID 91026975HCID 91026975, compound

Product 1

HCID 69065520HCID 69065520, compound

Reagents, catalysts & solvents 1

HCID 8007ButylamineSolvent

Procedure

A solution of 99 mg (0.21 mmol) (3S,6S,8R)-3,8-dimethyl-6-((2S,4R)-4-methyl-5-oxo-tetra-hydro-furan-2-yl)-1,1-dioxo-1lambda*6*-thia-5-aza-cyclohexadec-11-en-4-one in 1.5 ml butylamine is heated at 65° C. for two hours. The mixture is evaporated and the residue chromatographed on silica gel (EtOAc/hexane 1:1) to yield the title compound as a white solid.

Workup

  1. customThe mixture is evaporated
  2. customthe residue chromatographed on silica gel (EtOAc/hexane 1:1)

Sources & evidence

ORD record
ord-507ca7e36bc047bebed22ae0e7ee97b5
Source dataset
uspto-grants-2009_11
Patent number
US07612055B2

Reaction notes

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