HCID 68541620, compound → HCID 91026975, compound

Participants

Reaction Steps

Under a nitrogen atmosphere to 200 ml refluxing DCM is added a solution of 10 mg (0.01 mmol) tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene][benzylidine]ruthenium(IV)dichloride (‘Grubbs 2’ catalyst) in 1 ml DCM, followed by the dropwise addition of a solution of 100 mg (0.218 mmol) (S)-3-(hex-5-ene-1-sulfonyl)-2-methyl-N-[(1S,3R)-3-methyl-1-((2S,4R)-4-methyl-5-oxo-tetrahydro-furan-2-yl)hept-6-enyl]-propionamide in 5 ml DCM. After 2 h the mixture is cooled to rt and quenched by the addition of 0.05 ml butyl vinyl ether and 0.2 g activated charcoal. The mixture is passed through a pad of silica gel (EtOAc/hexane 1:1) to yield the title compound as a solid.

Provenance & Evidence