tert-Butanol → HCID 68541748, compound

Participants

Reaction Steps

A mixture of 2.09 g (6.67 mmol) [(R)-3-Methyl-6-oxo-1-(5-oxo-tetrahydro-furan-2-yl)-hexyl]-carbamic acid tert-butyl ester, 1.2 g (10 mol) NaH2PO4, 50 ml tBuOH and 10 ml water is subsequently treated with 20 ml of a 2M THF solution of 2-methyl-2-butene and 2.35 g (20.6 mmol) NaClO2 (technical, 80%). After stirring for 10 min the mixture is diluted with EtOAc and brine. The organic phase is dried with MgSO4, filtered and evaporated to yield the title compound as a resin which is used in the next step without purification.

Provenance & Evidence