Acetic Anhydride → HCID 86616387, compound

Participants

Reaction Steps

A mixture of [5-(4-amino-phenyl)-furan-2-yl]-(8-methyl-3,8-diaza-bicyclo[3.2.1]oct-3-yl)-methanone (0.40, 1.28 mmol), acetic acid anhydride (197 mg, 1.93 mmol) and dichloromethane (5 ml) was stirred at room temperature for 5 hours. Aqueous sodium hydroxide (5 ml, 1M) was added and the mixture was extracted twice with dichloromethane (2×10 ml). Chromatography on silica gel with dichloromethane, 10% methanol and 1% aqueous ammonia as solvent gave the title compound. The corresponding salt was obtained by addition of a diethyl ether and methanol mixture (9:1) saturated with fumaric acid. Mp. 257-259° C. Yield 515 mg (86%).

Provenance & Evidence