HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl-4-(4-nitro-pyridin-2-yl)-piperazine → 2-(4-Ethylpiperazin-1-yl)pyridin-4-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl-4-(4-nitro-pyridin-2-yl)-piperazine | HCID 68942070 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-(4-Ethylpiperazin-1-yl)pyridin-4-amine | HCID 61709572 | — |
Reaction Steps
A solution of 2.03 g (9 mmol) 1-ethyl-4-(4-nitro-pyridin-2-yl)-piperazine in 30 ml methanol was hydrogenated over 0.052 g Pd/C with 1 bar hydrogen for 3 h at room temperature. The mixture was filtered and evaporated to dryness to yield the title compound as yellow solid which was used without further purification (m/e): 207.1 (MH+; 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07612076B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-8ddd4b218af54354b611360b27695928 |
| Source note | uspto-grants-2009_11 |