Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | HCID 86605572 | HCID 86605572 | — |
| Catalyst | Copper | HCID 23978 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 68939390 | HCID 68939390 | 24% |
Reaction Steps
A mixture of 5.84 g (22 mmol) 1-(2-chloro-pyridin-4-yl)-4-cyclopentyl-piperazine, 0.8 g copper powder in 41 ml 7M ammonia in methanol was heated to 150° C. for 18 h. After evaporation to dryness the residue was purified on silica eluting with a gradient formed from dichloromethane/methanol and NEt3. The evaporation of the combined product fractions yielded 1.29 g (24%) of the title compound as yellowish solid. (m/e): 247.3 (MH+; 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07612076B2 |
|---|
| Source dataset | uspto-grants-2009_11 |
|---|
| ORD ID | ord-efcece09dcbf43fe8c5b84384efa92b0 |
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| Source note | uspto-grants-2009_11 |
|---|
