HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1432151Generated: October 26, 2026
1-Isopropylpiperazine → N-[2-(4-Isopropyl-piperazin-1-yl)-pyridin-4-yl]-N-methyl-acetamide
https://huagongshe.com/reaction/1432151
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Isopropylpiperazine | HCID 78013 | — |
| Reactant | N-(2-Chloro-4-pyridinyl)-N-methylacetamide | HCID 45119279 | — |
| Product | N-[2-(4-Isopropyl-piperazin-1-yl)-pyridin-4-yl]-N-methyl-acetamide | HCID 68941905 | — |
Reaction Steps
A mixture of 4 g (22 mmol) N-(2-chloro-pyridin-4-yl)-N-methyl-acetamide and 2.8 g (22 mmol) 1-(2-propyl)-piperazine was heated to 120° C. for 24 h. The crude product was purified by flash column chromatography on silica eluting with a gradient formed from heptane and ethyl acetate (0.1% NEt3) to yield after evaporation of the product fractions 2.5 g (41%) of the title compound as light brow oil. MS: (m/e): 277.2 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07612076B2 |
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| Source dataset | uspto-grants-2009_11 |
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| ORD ID | ord-c643291eae734ed1b33f336e85344664 |
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| Source note | uspto-grants-2009_11 |
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