4-Amino-1-Boc-piperidine → HCID 22182384, compound

HRID 1432188Notes

Reaction equation

HRID 1432188 reaction equation
Cl[C:2]1[C:3]2[CH:10]=[C:9]([CH2:11][CH:12]([CH3:14])[CH3:13])[S:8][C:4]=2[N:5]=[CH:6][N:7]=1.[NH2:15][CH:16]1[CH2:21][CH2:20][N:19]([C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[CH2:18][CH2:17]1>>[CH2:11]([C:9]1[S:8][C:4]2[N:5]=[CH:6][N:7]=[C:2]([NH:15][CH:16]3[CH2:17][CH2:18][N:19]([C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[CH2:20][CH2:21]3)[C:3]=2[CH:10]=1)[CH:12]([CH3:14])[CH3:13]

Participants

3

Reactant 2

HCID 12682914-Amino-1-Boc-piperidineHCID 22182430HCID 22182430, compound

Product 1

HCID 22182384HCID 22182384, compound

Procedure

The title compound was prepared (337 mg, 65%) from 4-chloro-6-isobutylthieno[2,3-d]pyrimidine (300 mg, 1.32 m. mol) and tert-butyl 4-aminopiperidine-1-carboxylate (400 mg, 1.99 m. mol) by following the general procedure described for Preparation 9. 1H NMR (400 MHz, CDCl3): δ 8.45 (s, 1H), 6.80 (s, 1H), 4.95 (m, 1H), 4.35 (m, 1H), 4.15 (m, 2H), 2.95 (m, 2H), 2.75 9d, 2H), 2.15 (m, 2H), 1.95 (m, 1H), 1.45 (s, 9H), 1.40-1.50 (m, 2H), 0.95 (d, 6H).

Workup

  1. customdescribed for Preparation 9

Sources & evidence

ORD record
ord-d2ed76bfbfed489a9e7d448470227a90
Source dataset
uspto-grants-2009_11
Patent number
US07612078B2

Reaction notes

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