Cyclohexanecarboxaldehyde → HCID 22182394, 화합물

HRID 1432192노트

반응식

HRID 1432192 반응식
[NH:1]1[CH2:6][CH2:5][CH:4]([NH:7][C:8](=[O:14])[O:9][C:10]([CH3:13])([CH3:12])[CH3:11])[CH2:3][CH2:2]1.[CH:15]1([CH:21]=O)[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1>>[CH:15]1([CH2:21][N:1]2[CH2:2][CH2:3][CH:4]([NH:7][C:8](=[O:14])[O:9][C:10]([CH3:11])([CH3:13])[CH3:12])[CH2:5][CH2:6]2)[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1

참가 물질

3

반응물 2

HCID 16275CyclohexanecarboxaldehydeHCID 7238334-(N-Boc-amino)piperidine

생성물 1

HCID 22182394HCID 22182394, 화합물

실험 절차

The title compound was prepared (1.83 g, 83%) from tert-butyl piperidin-4-ylcarbamate (1.50 g, 7.48 mmol) and cyclohexanecarbaldehyde (0.84 g, 7.48 mmol) by following the general procedure described for Preparation 3. 1H NMR (400 MHz, CDCl3) δ 4.80 (bs, 1H), 3.71 (m, 1H), 3.63 (m, 2H), 2.53 (m, 2H), 2.43 (m, 2H), 2.00-1.61 (m, 9H), 1.44 (s, 9H), 1.23 (m, 4H), 0.95 (m, 2H); MS (ESI) m/z: Calculated for C17H33N2O2, 297.25; Observed: 297.1 (M++1).

후처리

  1. customdescribed for Preparation 3

출처 및 근거

ORD 기록
ord-c5e19046229f46d89a35511865395a29
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07612078B2

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