1-(4-Fluorobenzyl)-2-(oxazol-2-yl)-5-methanesulfonyl-1H-pyrrolo[2,3-b]pyridine → 1-(4-Fluorobenzyl)-5-methanesulfonyl-2-(5-methyl-[1,2,4]oxadiazol-3-yl)indole

HRID 1432203Notes

Reaction equation

HRID 1432203 reaction equation
FC1C=CC(CN2C3C(=CC(S(C)(=O)=O)=CC=3)C=C2C2SC=CN=2)=CC=1.FC1C=CC(CN2C3=NC=C(S(C)(=O)=O)C=C3C=[C:34]2[C:46]2[O:47]C=C[N:50]=2)=CC=1.[F:53][C:54]1[CH:78]=[CH:77][C:57]([CH2:58][N:59]2[C:67]3[C:62](=[CH:63][C:64]([S:68]([CH3:71])(=[O:70])=[O:69])=[CH:65][CH:66]=3)[CH:61]=[C:60]2[C:72]2OC=N[N:76]=2)=[CH:56][CH:55]=1>>[F:53][C:54]1[CH:78]=[CH:77][C:57]([CH2:58][N:59]2[C:67]3[C:62](=[CH:63][C:64]([S:68]([CH3:71])(=[O:70])=[O:69])=[CH:65][CH:66]=3)[CH:61]=[C:60]2[C:72]2[N:50]=[C:46]([CH3:34])[O:47][N:76]=2)=[CH:56][CH:55]=1

Participants

4

Reactant 3

HCID 99293371-(4-Fluorobenzyl)-2-(oxazol-2-yl)-5-methanesulfonyl-1H-pyrrolo[2,3-b]pyridineHCID 154868551-(4-Fluorobenzyl)-5-methanesulfonyl-2-(thiazol-2-yl)indoleHCID 154868601-(4-Fluorobenzyl)-5-methanesulfonyl-2-([1,3,4]oxadiazol-2-yl)indole

Product 1

HCID 225044061-(4-Fluorobenzyl)-5-methanesulfonyl-2-(5-methyl-[1,2,4]oxadiazol-3-yl)indole

Procedure

Among the above compounds, 1-(4-fluorobenzyl)-5-methanesulfonyl-2-(thiazol-2-yl)indole; 1-(4-fluorobenzyl)-2-(oxazol-2-yl)-5-methanesulfonyl-1H-pyrrolo [2,3-b]pyridine; and 1-(4-fluorobenzyl)-5-methanesulfonyl-2-([1,3,4]oxadiazol-2-yl)indole and addition salts thereof with a pharmaceutically acceptable acid or base, and hydrates thereof are particularly preferred.

Sources & evidence

ORD record
ord-e26fc44cc5ca424db5e0ca19ea864136
Source dataset
uspto-grants-2009_11
Patent number
US07612070B2

Reaction notes

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