Potassium Hydroxide → HCID 22504368, compound

HRID 1432230Notes

Reaction equation

HRID 1432230 reaction equation
C1(S([N:10]2[C:14]3=[N:15][CH:16]=[C:17]([S:19]([CH3:22])(=[O:21])=[O:20])[CH:18]=[C:13]3[CH:12]=[C:11]2[C:23]2[O:24][C:25]([CH3:28])=[CH:26][CH:27]=2)(=O)=O)C=CC=CC=1.[OH-].[K+]>CO>[CH3:22][S:19]([C:17]1[CH:18]=[C:13]2[CH:12]=[C:11]([C:23]3[O:24][C:25]([CH3:28])=[CH:26][CH:27]=3)[NH:10][C:14]2=[N:15][CH:16]=1)(=[O:21])=[O:20]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 22504381HCID 22504381, compound

Product 1

HCID 22504368HCID 22504368, compoundYield 90.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

To a mixture solution of the compound obtained in Example 11 (2) (421 mg) in methanol (60 ml), a 1N aqueous potassium hydroxide solution (3 ml) was added and the mixture was stirred at 60° C. for 1 hour. The reaction solution was then concentrated under reduced pressure. The residue was washed with water and ether and dried to obtain 252 mg of the desired product as a yellow powder.

Workup

  1. concentrationThe reaction solution was then concentrated under reduced pressure
  2. washThe residue was washed with water and ether
  3. customdried

Sources & evidence

ORD record
ord-c8c9fb2baa784fee9e61b1614b6c5e9b
Source dataset
uspto-grants-2009_11
Patent number
US07612070B2

Reaction notes

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