Ethylene Glycol → 1-(4-Fluorobenzyl)-5-methanesulfonyl-2-(2-thiazolylmethyl)indole

関与物質

反応条件

反応手順

To a mixture of the compound obtained in Example 27 (6) (88 mg), potassium hydroxide. (25 mg) and ethylene glycol (2.5 ml), hydrazine. (65-mg) was added and the mixture was stirred at 120° C. for 3 hours. The reaction mixture was poured into water, extracted with chloroform, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The resulting residue was separated and purified twice with silica gel preparative thin-layer chromatography (hexane:ethyl acetate=1:1) and (chloroform:methanol=15:1) to obtain 39 mg of the desired product as a yellow oil.

情報源と証拠