Butylamine → HCID 86612517, compound

HRID 1432341Notes

Reaction equation

HRID 1432341 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][CH:10]([NH:18][C:19]([C:21]2[C:27]3[CH:28]=[CH:29][CH:30]=[CH:31][C:26]=3[O:25][C:24]3[CH:32]=[CH:33][CH:34]=[CH:35][C:23]=3[CH:22]=2)=[O:20])[CH:11]2[CH2:15][CH:14]([CH3:16])[C:13](=[O:17])[O:12]2)[CH:5]=[C:6]([F:8])[CH:7]=1.[CH2:36]([NH2:40])[CH2:37][CH2:38][CH3:39]>>[CH2:36]([NH:40][C:13]([CH:14]([CH3:16])[CH2:15][CH:11]([OH:12])[CH:10]([NH:18][C:19]([C:21]1[C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][C:26]=2[O:25][C:24]2[CH:32]=[CH:33][CH:34]=[CH:35][C:23]=2[CH:22]=1)=[O:20])[CH2:9][C:4]1[CH:5]=[C:6]([F:8])[CH:7]=[C:2]([F:1])[CH:3]=1)=[O:17])[CH2:37][CH2:38][CH3:39]

Participants

3

Reactant 2

HCID 8007ButylamineHCID 86612518HCID 86612518, compound

Product 1

HCID 86612517HCID 86612517, compound

Procedure

Dibenzo[b,f]oxepine-10-carboxylic acid [2-(3,5-difluoro-phenyl)-1-(4-methyl-5-oxo-tetrahydrofuran-2-yl)-ethyl]-amide (50 mg, 0.105 mmol) is dissolved in 2 ml butylamine and stirred for 16 h. The solution is concentrated in vacuo and the residual solid recrystallized from EtOAc/hexane. Yield 27 mg (48%).

Workup

  1. concentrationThe solution is concentrated in vacuo
  2. customthe residual solid recrystallized from EtOAc/hexane

Sources & evidence

ORD record
ord-57283b9ee7444990b5620da211b5dd22
Source dataset
uspto-grants-2009_11
Patent number
US07612054B2

Reaction notes

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