HCID 86612520, compound → HCID 86612519, compound

HRID 1432342Notes

Reaction equation

HRID 1432342 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:8][CH:9]([NH:17][C:18]([C:20]2[C:26]3[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=3[O:24][C:23]3[CH:31]=[CH:32][CH:33]=[CH:34][C:22]=3[CH:21]=2)=[O:19])[CH:10]2[CH2:14][CH:13]([CH3:15])[C:12](=[O:16])[O:11]2)[CH:5]=[CH:6][CH:7]=1>C(N)CCC>[CH2:9]([NH:17][C:12]([CH:13]([CH3:15])[CH2:14][CH:10]([OH:11])[CH:9]([NH:17][C:18]([C:20]1[C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=2[O:24][C:23]2[CH:31]=[CH:32][CH:33]=[CH:34][C:22]=2[CH:21]=1)=[O:19])[CH2:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[CH:3]=1)=[O:16])[CH2:8][CH2:4][CH3:3]

Participants

3

Reactant 1

HCID 86612520HCID 86612520, compound

Product 1

HCID 86612519HCID 86612519, compound

Reagents, catalysts & solvents 1

HCID 8007ButylamineSolvent

Procedure

Dibenzo[b,f]oxepine-10-carboxylic acid [2-(3-fluoro-phenyl)-1-(4-methyl-5-oxo-tetrahydrofuran-2-yl)-ethyl]-amide (50 mg) is dissolved in 2 ml butylamine and stirred for 16 h. The solution was concentrated in vacuo and the residual solid was recrystallised from EtOAc/hexane. Yield 25 mg (48%).

Workup

  1. concentrationThe solution was concentrated in vacuo
  2. customthe residual solid was recrystallised from EtOAc/hexane

Sources & evidence

ORD record
ord-9a3114b37be24db19228c3021a6b7f36
Source dataset
uspto-grants-2009_11
Patent number
US07612054B2

Reaction notes

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