4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-5-yl)benzoic acid → 4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-5-yl)cyclohexanecarboxylic acid

HRID 1432346Notes

Reaction equation

HRID 1432346 reaction equation
[CH:1]1[N:2]=[CH:3][N:4]2[CH:9]([C:10]3[CH:18]=[CH:17][C:13]([C:14]([OH:16])=[O:15])=[CH:12][CH:11]=3)[CH2:8][CH2:7][CH2:6][C:5]=12>C(O)(=O)C>[CH:1]1[N:2]=[CH:3][N:4]2[CH:9]([CH:10]3[CH2:18][CH2:17][CH:13]([C:14]([OH:16])=[O:15])[CH2:12][CH2:11]3)[CH2:8][CH2:7][CH2:6][C:5]=12

Participants

3

Reactant 1

HCID 136882154-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-5-yl)benzoic acid

Product 1

HCID 685495614-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-5-yl)cyclohexanecarboxylic acid

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 1.5 g of 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzoic acid [93178-73-5] in 5 ml of acetic acid is hydrogenated (50 bar) in the presence 0.05 g of Nishimura catalyst at room temperature. The reaction mixture is clarified by filtration, and the filtrate is evaporated. The crude title compound is obtained from the residue.

Workup

  1. customat room temperature
  2. filtrationThe reaction mixture is clarified by filtration
  3. customthe filtrate is evaporated

Sources & evidence

ORD record
ord-a27286a4082a44739535500fd007e9f0
Source dataset
uspto-grants-2009_11
Patent number
US07612088B2

Reaction notes

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