Sulfuric Acid → HCID 68547112, compound

Participants

Reaction Steps

0.14 ml of conc. H2SO4 are added dropwise to a suspension of 0.19 g of lithiumaluminium hydride and 10 ml of terahydrofuran at 0° C. After stirring for 30 minutes a solution of 0.41 g of 3-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-8-yl)pyrrolidin-2-one and 10 ml of tetrahydrofuran is added dropwise, and the mixture is then warmed to room temperature. After 1 hour, the reaction mixture is cooled to 0° C. and quenched successively with 1 ml of tetrahydrofuran/water (1:1) and 3 ml of 5% NaOH. The precipitate is filtered off and washed with tetrahydrofuran (2×)—the combined organic phases are dried with sodium sulphate and evaporated. The crude title compound is obtained from the residue.

Provenance & Evidence