Sodium Hydroxide → 871328-39-1

HRID 1432351Notes

Reaction equation

HRID 1432351 reaction equation
[OH-].[Na+].[S:3]1[C:7]2[CH2:8][CH2:9][CH:10]([C:12]([O:14]CC)=[O:13])[CH2:11][C:6]=2[N:5]=[CH:4]1>CO>[S:3]1[C:7]2[CH2:8][CH2:9][CH:10]([C:12]([OH:14])=[O:13])[CH2:11][C:6]=2[N:5]=[CH:4]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 13424804HCID 13424804, compound

Product 1

HCID 68552307871328-39-1

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

6 ml of 2N NaOH are added to a solution of 0.42 g of ethyl 4,5,6,7-tetrahydrobenzothiazole-5-carboxylate [952203-30-8] and 24 ml of MeOH at room temperature. After 6 hours, the reaction mixture is evaporated. The residue is acidified with 4N HCl, diluted with water and extracted with ethyl acetate (2×)—the combined organic phases are dried with sodium sulphate and evaporated. The crude title compound is obtained from the residue.

Workup

  1. customthe reaction mixture is evaporated
  2. additiondiluted with water
  3. extractionextracted with ethyl acetate (2×)—the combined organic phases
  4. dry with materialare dried with sodium sulphate
  5. customevaporated

Sources & evidence

ORD record
ord-2d395f3bf35e485a8aeafc3f85cc22c1
Source dataset
uspto-grants-2009_11
Patent number
US07612088B2

Reaction notes

Loading…