3-Nitroaniline → HCID 178526635, compound

Participants

Reaction Steps

2,6-Dichloro-9H-purine (650 mg, 3.44 mmol) and 3-nitroaniline (1.9 g, 13.76 mmol) were stirred in 1-pentanol (5 mL) at 100° C. for 2 h under N2. The mixture was cooled and diluted with Et2O (40 mL). The precipitate was filtered and washed successively on a sinter with Et2O, PriOH, H2O, 10% aq Na2CO3, H2O, PriOH, and Et2O (2×20 mL each). It was then dried in vacuo to afford the title compound as a lemon-yellow powder (1.01 g, quant.). TLC (9:1 CH2Cl2/MeOH): RF=0.35.

Provenance & Evidence