Water → HCID 17954008, compound

Participants

Reaction Steps

(2-Chloro-9H-purin-6-yl)-(3-nitro-phenyl)-amine (872 mg, 3 mmol) was dissolved in dry DMF (10 mL). NaH (122 mg, 5.1 mmol) was added in portions and the resulting mixture was stirred for 1 h. 2-Bromopropane (480 mg, 3.9 mmol) was then added and the reaction was stirred overnight at 80° C. under N2. After cooling, H2O (50 mL) was added slowly with stirring and cooling. After 1 h, precipitated product was filtered, washed with more cold H2O, and dried in vacuo to afford the title compound as a lemon-yellow powder (905 mg, 90.7%). TLC (95:5 CH2Cl2/MeOH): RF=0.46.

Provenance & Evidence