HCID 11627625, compound → HCID 11696504, compound

Participants

Reaction Steps

Palladium on activated carbon (0.017 g) was added to a solution of {4-[4-Benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-cyclohexyl}-carbamic acid benzyl ester (see Example 18; 0.370 g, 0.725 mmol) in methanol (5 mL). The reaction mixture was stirred under hydrogen atmosphere for 4 hours. The mixture was then filtered and concentrated to give 0.250 g (92%) of the title compound as a yellow oil. MS (ESP+) m/z 377.2 (M+1). 1H NMR (300 MHz, Methanol-d4) δ 7.80 (t, 1H, J=7.8 Hz), 7.36 (m, 2H), 7.01 (m, 3H), 6.07 (s, 2H), 3.47 (m, 1H), 3.32 (m, 1H), 2.29 (m, 2H), 2.03 (m, 4H), 1.90 (m, 2H).

Provenance & Evidence