N-Acetyltryptamine → N-(2-{2-[(3,5-Difluoro-phenyl)-(4-hydroxy-5-isopropyl-2-oxo-2,5-dihydro-1H-pyrrol-3-yl)-methyl]-1H-indol-3-yl}-ethyl)-acetamide

HRID 1432444Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1432444
[OH:1][C:2]1[CH:6]([CH:7]([CH3:9])[CH3:8])[NH:5][C:4](=[O:10])[CH:3]=1.[F:11][C:12]1[CH:13]=[C:14]([CH:17]=[C:18]([F:20])[CH:19]=1)[CH:15]=O.[NH:21]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[C:23]([CH2:30][CH2:31][NH:32][C:33](=[O:35])[CH3:34])=[CH:22]1>>[F:11][C:12]1[CH:13]=[C:14]([CH:15]([C:3]2[C:4](=[O:10])[NH:5][CH:6]([CH:7]([CH3:9])[CH3:8])[C:2]=2[OH:1])[C:22]2[NH:21][C:29]3[C:24]([C:23]=2[CH2:30][CH2:31][NH:32][C:33](=[O:35])[CH3:34])=[CH:25][CH:26]=[CH:27][CH:28]=3)[CH:17]=[C:18]([F:20])[CH:19]=1

Komponenten

4

Edukt 3

HCID 70547N-AcetyltryptamineHCID 5881603,5-DifluorobenzaldehydeHCID 566041114-Hydroxy-5-isopropyl-1,5-dihydro-pyrrol-2-one

Produkt 1

HCID 57933437N-(2-{2-[(3,5-Difluoro-phenyl)-(4-hydroxy-5-isopropyl-2-oxo-2,5-dihydro-1H-pyrrol-3-yl)-methyl]-1H-indol-3-yl}-ethyl)-acetamide

Versuchsvorschrift

Using general procedure C, 4-hydroxy-5-isopropyl-1,5-dihydro-pyrrol-2-one (Lit. 11) was reacted with 3,5-difluoro-benzaldehyde and N-[2-(1H-indol-3-yl)-ethyl]-acetamide to give the title compound as a yellow solid. MS: 468.0 ([M+H]+).

Quellen und Nachweise

ORD-Eintrag
ord-fa2debcb10114808bd803f826d398071
Quelldatensatz
uspto-grants-2009_11
Patentnummer
US07612099B2

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