Lithium Hydroxide → HCID 57933451, compound

Participants

Reaction Steps

A solution of acetic acid 2-{2-[(4-hydroxy-5-isopropyl-2-oxo-2,5-dihydro-1H-pyrrol-3-yl)-phenyl-methyl]-1H-indol-3-yl}-ethyl ester (40 mg) and LiOH (8.5 mg ) in MeOH (0.5 ml) was stirred at 22° C. for 30 min and evaporated. The residue was partitioned between 0.1 N aqueous HCl and AcOEt and the organic layer was dried and evaporated. The residue was chromatographed on silica using CH2Cl2/MeOH (10:3) to give the title compound as an orange foam. MS: 391.1 ([M+H]+).

Provenance & Evidence