HRID1432448

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID240

Benzaldehyde

C7H6O

结构：O=C(NCCc1c[nH]c2ccccc12)c1cc(C(F)(F)F)cc(C(F)(F)F)c1

HCID22574444

未命名化合物

HCID56604111

未命名化合物

PRODUCTS

生成物

结构：CC(C)C1NC(=O)C(C(c2ccccc2)c2[nH]c3ccccc3c2CCNC(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)=C1O

HCID57933450

未命名化合物

PROCEDURE

实验过程

Using general procedure C, 4-hydroxy-5-isopropyl-1,5-dihydro-pyrrol-2-one (Lit. 11) was reacted with benzaldehyde and N-[2-(1H-Indol-3-yl)-ethyl]-3,5-bis-trifluoromethyl-benzamide to give N-(2-{2-[(4-hydroxy-5-isopropyl-2-oxo-2,5-dihydro-1H-pyrrol-3-yl)-phenyl-methyl]-1H-indol-3-yl}-ethyl)-3,5-bis-trifluoromethyl-benzamide as a red solid. MS: 630.2 ([M+H]+).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-417b4ab9312c43d89dd42747d9f42d32
来源数据集: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07612099B2
来源说明: uspto-grants-2009_11

反应 SMILES

[OH:1][C:2]1[CH:6]([CH:7]([CH3:9])[CH3:8])[NH:5][C:4](=[O:10])[CH:3]=1.[CH:11](=O)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[NH:19]1[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[C:21]([CH2:28][CH2:29][NH:30][C:31](=[O:46])[C:32]2[CH:37]=[C:36]([C:38]([F:41])([F:40])[F:39])[CH:35]=[C:34]([C:42]([F:45])([F:44])[F:43])[CH:33]=2)=[CH:20]1>>[OH:1][C:2]1[CH:6]([CH:7]([CH3:9])[CH3:8])[NH:5][C:4](=[O:10])[C:3]=1[CH:11]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:20]1[NH:19][C:27]2[C:22]([C:21]=1[CH2:28][CH2:29][NH:30][C:31](=[O:46])[C:32]1[CH:33]=[C:34]([C:42]([F:43])([F:44])[F:45])[CH:35]=[C:36]([C:38]([F:41])([F:39])[F:40])[CH:37]=1)=[CH:23][CH:24]=[CH:25][CH:26]=2