o-Fluorobenzaldehyde → HCID 57933454, compound

HRID 1432464Notes

Reaction equation

HRID 1432464 reaction equation
[CH2:1]([CH:8]1[O:12][C:11](=[O:13])[CH:10]=[C:9]1[OH:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:15][C:16]1[CH:23]=[CH:22][CH:21]=[CH:20][C:17]=1[CH:18]=O.[NH:24]1[C:32]2[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=2)[C:26]([CH2:33][CH2:34][NH:35][C:36](=[O:38])[CH3:37])=[CH:25]1>>[CH2:1]([CH:8]1[O:12][C:11](=[O:13])[C:10]([CH:18]([C:17]2[CH:20]=[CH:21][CH:22]=[CH:23][C:16]=2[F:15])[C:25]2[NH:24][C:32]3[C:27]([C:26]=2[CH2:33][CH2:34][NH:35][C:36](=[O:38])[CH3:37])=[CH:28][CH:29]=[CH:30][CH:31]=3)=[C:9]1[OH:14])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 67970o-FluorobenzaldehydeHCID 70547N-AcetyltryptamineHCID 690635555-benzyl-4-hydroxy-5H-furan-2-one

Product 1

HCID 57933454HCID 57933454, compound

Procedure

Using general procedure C, 5-benzyl-4-hydroxy-5H-furan-2-one (Lit. 13) was reacted with 2-fluoro-benzaldehyde and N-[2-(1H-indol-3-yl)-ethyl]-acetamide) to give the title compound as a white solid. MS: 497.3 ([M−H]−).

Sources & evidence

ORD record
ord-152f272094f24b00983a0d3cc1b082aa
Source dataset
uspto-grants-2009_11
Patent number
US07612099B2

Reaction notes

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