Benzaldehyde → N-(2-{6-Fluoro-2-[(4-hydroxy-2-oxo-5-phenyl-2,5-dihydro-furan-3-yl)-phenyl-methyl]-1H-indol-3-yl)-ethyl)-acetamide

Participants

Role	Name	HCID	Charge
Reactant	Benzaldehyde	HCID 240	—
Reactant	N-[2-(6-Fluoro-1H-indol-3-yl)-ethyl]-acetamide	HCID 10751398	—
Reactant	4-Hydroxy-5-phenylfuran-2(5H)-one	HCID 54694569	—
Product	N-(2-{6-Fluoro-2-[(4-hydroxy-2-oxo-5-phenyl-2,5-dihydro-furan-3-yl)-phenyl-methyl]-1H-indol-3-yl)-ethyl)-acetamide	HCID 57933458	—

Reaction Steps

Using general procedure C, 4-hydroxy-5-phenyl-5H-furan-2-one (Lit. 14) was reacted with benzaldehyde and N-[2-(6-fluoro-1H-indol-3-yl)-ethyl]-acetamide (Example 18.1.) to give the title compound as pale brown solid. MS: 485.0 ([M+H]+).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07612099B2
Source dataset	uspto-grants-2009_11
ORD ID	ord-84760ccd20344a71848fdda31d8b11cc
Source note	uspto-grants-2009_11