Benzaldehyde → N-(2-{6-Fluoro-2-[(4-hydroxy-5-methyl-2-oxo-5-phenyl-2,5-dihydro-furan-3-yl)-phenyl-methyl]-1H-indol-3-yl}-ethyl)-acetamide

Participants

Role	Name	HCID	Charge
Reactant	Benzaldehyde	HCID 240	—
Reactant	N-[2-(6-Fluoro-1H-indol-3-yl)-ethyl]-acetamide	HCID 10751398	—
Reactant	4-hydroxy-5-methyl-5-phenyl-5H-furan-2-one	HCID 69068481	—
Product	N-(2-{6-Fluoro-2-[(4-hydroxy-5-methyl-2-oxo-5-phenyl-2,5-dihydro-furan-3-yl)-phenyl-methyl]-1H-indol-3-yl}-ethyl)-acetamide	HCID 57933423	—

Reaction Steps

Using general procedure C, 4-hydroxy-5-methyl-5-phenyl-5H-furan-2-one (Example A2) was reacted with benzaldehyde and N-[2-(6-fluoro-1H-indol-3-yl)-ethyl]-acetamide (Example 18.1.) to give the title compound as pale brown solid. MS: 499.5 ([M+H]+).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07612099B2
Source dataset	uspto-grants-2009_11
ORD ID	ord-1511eb5b999a41b5943341611ca42d95
Source note	uspto-grants-2009_11