Benzaldehyde → N-(2-{2-[(5-Cyclohexylmethyl-4-hydroxy-2-oxo-2,5-dihydro-furan-3-yl)-phenyl-methyl]-6-fluoro-1H-indol-3-yl}-ethyl)-acetamide

Participants

Role	Name	HCID	Charge
Reactant	Benzaldehyde	HCID 240	—
Reactant	N-[2-(6-Fluoro-1H-indol-3-yl)-ethyl]-acetamide	HCID 10751398	—
Reactant	5-cyclohexylmethyl-4-hydroxy-5H-furan-2-one	HCID 69069623	—
Product	N-(2-{2-[(5-Cyclohexylmethyl-4-hydroxy-2-oxo-2,5-dihydro-furan-3-yl)-phenyl-methyl]-6-fluoro-1H-indol-3-yl}-ethyl)-acetamide	HCID 57933470	—

Reaction Steps

Using general procedure C, 5-cyclohexylmethyl-4-hydroxy-5H-furan-2-one (Lit. 13) was reacted with benzaldehyde and N-[2-(6-fluoro-1H-indol-3-yl)-ethyl]-acetamide (Example 18.1.) to give the title compound as pale red solid. MS: 503.0 ([M−H]−).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07612099B2
Source dataset	uspto-grants-2009_11
ORD ID	ord-956ebefb56414fe0864f2f7fbef41e4c
Source note	uspto-grants-2009_11