HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzaldehyde → 3-[(5-Fluoro-3-methyl-1h-indol-2-yl)-phenyl-methyl]-4-hydroxy-5,5-dimethyl-1,5-dihydro-pyrrol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzaldehyde | HCID 240 | — |
| Reactant | 5-Fluoro-3-methyl-1H-indole | HCID 22351503 | — |
| Reactant | 4-hydroxy-5,5-dimethyl-1,5-dihydro-2H-pyrrol-2-one | HCID 66725429 | — |
| Product | 3-[(5-Fluoro-3-methyl-1h-indol-2-yl)-phenyl-methyl]-4-hydroxy-5,5-dimethyl-1,5-dihydro-pyrrol-2-one | HCID 57933438 | — |
Reaction Steps
Using general procedure D, rac-4-hydroxy-5,5-dimethyl-1,5-dihydro-pyrrol-2-one (Lit. 18) was reacted with benzaldehyde and 5-fluoro-3-methyl-1H-indole to give the title compound as a yellow solid. MS: 365.1 ([M+H]+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07612099B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-2873d50e40164cbf97480dfbd76a51b9 |
| Source note | uspto-grants-2009_11 |