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Benzaldehyde → (R)-4-Hydroxy-5-methyl-3-[(3-methyl-1H-indol-2-yl)-phenyl-methyl]-5-phenyl-1,5-dihydro-pyrrol-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzaldehyde | HCID 240 | — |
| 反応物 | Skatole | HCID 6736 | — |
| 反応物 | (R)-4-hydroxy-5-methyl-5-phenyl-1,5-dihydro-pyrrol-2-one | HCID 69071890 | — |
| 生成物 | (R)-4-Hydroxy-5-methyl-3-[(3-methyl-1H-indol-2-yl)-phenyl-methyl]-5-phenyl-1,5-dihydro-pyrrol-2-one | HCID 57933473 | — |
反応手順
Using general procedure D, (R)-4-hydroxy-5-methyl-5-phenyl-1,5-dihydro-pyrrol-2-one (prepared according to Lit. 11, see also Lit. 19) was reacted with benzaldehyde and 3-methyl-1H-indole to give the title compound as a yellow foam. MS: 409.2 ([M+H]+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07612099B2 |
| 出典データセット | uspto-grants-2009_11 |
| ORD ID | ord-f3a41c59fda74680a6010a435d1b7497 |
| 出典メモ | uspto-grants-2009_11 |