HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzaldehyde → (R)-3-[(3,5-Dimethyl-1H-indol-2-yl)-phenyl-methyl]-4-hydroxy-5-methyl-5-phenyl-1,5-dihydro-pyrrol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzaldehyde | HCID 240 | — |
| Reactant | 3,5-Dimethylindole | HCID 98615 | — |
| Reactant | (R)-4-hydroxy-5-methyl-5-phenyl-1,5-dihydro-pyrrol-2-one | HCID 69071890 | — |
| Product | (R)-3-[(3,5-Dimethyl-1H-indol-2-yl)-phenyl-methyl]-4-hydroxy-5-methyl-5-phenyl-1,5-dihydro-pyrrol-2-one | HCID 57933441 | — |
Reaction Steps
Using general procedure D, (R)-4-hydroxy-5-methyl-5-phenyl-1,5-dihydro-pyrrol-2-one (prepared according to Lit. 11, see also Lit. 19) was reacted with benzaldehyde and 3,5-dimethyl-1H-indole (Lit. 21) to give the title compound as a yellow foam. MS: 423.3 ([M+H]+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07612099B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-d0b569313487446d813e15f877e43a32 |
| Source note | uspto-grants-2009_11 |