2-Thiophenecarboxaldehyde → HCID 57933417, compound

HRID 1432506Notes

Reaction equation

HRID 1432506 reaction equation
[CH2:1]([CH:8]1[O:12][C:11](=[O:13])[CH:10]=[C:9]1[OH:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[S:15]1[CH:19]=[CH:18][CH:17]=[C:16]1[CH:20]=O.[F:22][C:23]1[CH:24]=[C:25]2[C:29](=[CH:30][CH:31]=1)[NH:28][CH:27]=[C:26]2[CH3:32]>>[CH2:1]([CH:8]1[O:12][C:11](=[O:13])[C:10]([CH:20]([C:27]2[NH:28][C:29]3[C:25]([C:26]=2[CH3:32])=[CH:24][C:23]([F:22])=[CH:31][CH:30]=3)[C:16]2[S:15][CH:19]=[CH:18][CH:17]=2)=[C:9]1[OH:14])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 73642-ThiophenecarboxaldehydeHCID 223515035-Fluoro-3-methyl-1H-indoleHCID 690635555-benzyl-4-hydroxy-5H-furan-2-one

Product 1

HCID 57933417HCID 57933417, compound

Procedure

Using general procedure D, rac-5-benzyl-4-hydroxy-5H-furan-2-one (Lit. 13) was reacted with thiophene-2-carbaldehyde and 5-fluoro-3-methyl-1H-indole to give the title compound as a red solid. MS: 434.3 ([M+H]+).

Sources & evidence

ORD record
ord-f10f866261d84b63b5ff9707a3d1707a
Source dataset
uspto-grants-2009_11
Patent number
US07612099B2

Reaction notes

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