HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzaldehyde → N-(2-(5-Chloro-2-[(4-hydroxy-5-methyl-2-oxo-5-phenyl-2,5-dihydro-furan-3-yl)-phenyl-methyl]-1H-indol-3-yl}-1,1-dimethyl-ethyl)-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzaldehyde | HCID 240 | — |
| Reactant | 4-hydroxy-5-methyl-5-phenyl-5H-furan-2-one | HCID 69068481 | — |
| Reactant | n-[2-(5-Chloro-1h-indol-3-yl)-1,1-dimethyl-ethyl]-acetamide | HCID 69068794 | — |
| Product | N-(2-(5-Chloro-2-[(4-hydroxy-5-methyl-2-oxo-5-phenyl-2,5-dihydro-furan-3-yl)-phenyl-methyl]-1H-indol-3-yl}-1,1-dimethyl-ethyl)-acetamide | HCID 57933411 | — |
Reaction Steps
Using general procedure D, rac-4-hydroxy-5-methyl-5-phenyl-5H-furan-2-one (prepared according to Example A3) was reacted with benzaldehyde and N-[2-(5-chloro-1H-indol-3-yl)-1,1-dimethyl-ethyl]-acetamide to give the title compound as pale brown solid. MS: 543.3 ([M+H]+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07612099B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-4eabdab72bec4eb7991372c4dadd432f |
| Source note | uspto-grants-2009_11 |