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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1432508Generated: October 31, 2026

Benzaldehyde → N-(2-(5-Chloro-2-[(4-hydroxy-5-methyl-2-oxo-5-phenyl-2,5-dihydro-furan-3-yl)-phenyl-methyl]-1H-indol-3-yl}-1,1-dimethyl-ethyl)-acetamide

https://huagongshe.com/reaction/1432508

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzaldehydeHCID 240—
Reactant4-hydroxy-5-methyl-5-phenyl-5H-furan-2-oneHCID 69068481—
Reactantn-[2-(5-Chloro-1h-indol-3-yl)-1,1-dimethyl-ethyl]-acetamideHCID 69068794—
ProductN-(2-(5-Chloro-2-[(4-hydroxy-5-methyl-2-oxo-5-phenyl-2,5-dihydro-furan-3-yl)-phenyl-methyl]-1H-indol-3-yl}-1,1-dimethyl-ethyl)-acetamideHCID 57933411—

Reaction Steps

Using general procedure D, rac-4-hydroxy-5-methyl-5-phenyl-5H-furan-2-one (prepared according to Example A3) was reacted with benzaldehyde and N-[2-(5-chloro-1H-indol-3-yl)-1,1-dimethyl-ethyl]-acetamide to give the title compound as pale brown solid. MS: 543.3 ([M+H]+).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07612099B2
Source datasetuspto-grants-2009_11
ORD IDord-4eabdab72bec4eb7991372c4dadd432f
Source noteuspto-grants-2009_11